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DNA and RNA Production: Folate, along with vitamin B12, helps create DNA and RNA, which are necessary for cell growth and division

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Important for this review is the concept that M1 and M2 macrophages display distinct metabolic profiles that, in some cases, directly correspond to their disparate phenotypes and functionality ( Classically activated (M1) macrophages arise following exposure to interferon-γ (IFNγ) and/or tumor necrosis factor (TNF), express high levels of cytokines IL-1, IL-6, and IL-23, and are adept at producing ROS, all traits as possible which make them highly effective killers during infection or in response to cancer